Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Seukeran DC, Cunliffe WJ. The treatment of acne fulminans: a review of 25 cases. Br J Dermatol. 1999 Aug. Ask your healthcare professional how you should dispose of any medicine you do not use. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. buy toprol cream uk toprol
If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. To help isotretinoin work properly, use sunscreen or sunblock lotions with a sun protection factor SPF of at least 15 on a regular basis. Also, wear protective clothing and hats. Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
Use and dose must be determined by your doctor. This is what accutane does. You will have to have apply lotion multiple times a day. I showered in the morning and at night and applied lotion Aveeno after my showers. The safety of once daily dosing with Claravis has not been established. Once daily dosing is not recommended. Williamson DM, Cunliffe WJ, Gatecliff M, Scott DG. Acute ulcerative acne conglobata acne fulminans with erythema nodosum. Clin Exp Dermatol. 1977 Dec.
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Taking too much acetaminophen may cause serious possibly fatal liver disease. Adults should not take more than 4000 milligrams 4 grams of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.
If you are giving acetaminophen to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age. It takes some time to see results though. Accutane does in fact reduce the amount of oil that your sebaceous glands will produce. I started to see results about 2 or 3 months into treatment. Remember that it may become a bit worse until you start to see improvement. Papilledema occurred as a sign of benign intracranial hypertension. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Patients may discontinue treatment if the total nodule count has reduced by at least 70% before completing the 15 to 20-week treatment. I'm sorry to hear about all the side effects that accutane is causing you. However, this is all normal. The first time I was prescribed accutane, my skin cracked all over, I had to take lotion to school to apply to my skin. I looked horrible with acne, red skin, and dry skin. However don't worry! Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Kraus SL, Emmert S, Schön MP, Haenssle HA. The dark side of beauty: acne fulminans induced by anabolic steroids in a male bodybuilder. Arch Dermatol. Oct 2012. Depression symptoms have been reported to disappear after discontinuation of the drug and reappear when treatment is resumed. This section provides information on the proper use of a number of products that contain isotretinoin. It may not be specific to Accutane. Please read with care.
Back pain occurred more frequently in children and adolescent patients. Contraceptive measures must be followed for any subsequent course of therapy see PRECAUTIONS. Kim SY, Jung SK, Lee SG, Yi SM, Kim JH, Kim IH. Acne fulminans with osteolytic change in metaphysis of distal radius. Int J Dermatol. 2016 May. During the first 3 weeks you are taking isotretinoin, your skin may become irritated. Also, your acne may seem to get worse before it gets better. Check with your doctor if your skin condition does not improve within 1 to 2 months after starting this medicine or at any time your skin irritation becomes severe. Full improvement continues after you stop taking isotretinoin and may take up to 6 months. Your doctor can help you choose the right skin products to reduce skin dryness and irritation. Sarifakioglu E, Onur O, Kart H, Yilmaz AE. Acute myopathy and acne fulminans triggered by isotretinoin therapy. Eur J Dermatol. Sep-Oct 2011. It is very important that you take isotretinoin only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. Appropriate studies have not been performed on the relationship of age to the effects of isotretinoin in children younger than 12 years of age. Safety and efficacy have not been established. Windom RE, Sanford JP, Ziff M. Acne conglobata and arthritis. Arthritis Rheum. 1961 Dec. If the total nodule count has been reduced by more than 70% prior to completing 15 to 20 weeks of treatment, the drug may be discontinued. After a period of 2 months or more off therapy, and if warranted by persistent or recurring severe nodular acne, a second course of therapy may be initiated. The optimal interval before retreatment has not been defined for patients who have not completed skeletal growth. Long-term use of Accutane, even in low doses, has not been studied, and is not recommended. It is important that Accutane be given at the recommended doses for no longer than the recommended duration. Due to high teratogenicity and to minimize fetal exposure, this drug is available only through a special restricted distribution program called iPLEDGE TM. Prescribers, pharmacies, and wholesalers must be registered and activated with the iPLEDGE program in order to prescribe, dispense, or distribute this drug. This drug must only be dispensed to patients who are registered and meet all the requirements of iPLEDGE. This registration process ensures that prescribers, pharmacists, and patients agree to assume specific responsibilities to ensure that patients do not become pregnant while taking this drug and do not get prescribed the medicine if they are pregnant. Further details on iPLEDGE are available at www. Leyden JJ. The role of isotretinoin in the treatment of acne: personal observations. J Am Acad Dermatol. 1998 Aug. Some of the side effects that can occur with isotretinoin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If you are taking this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Bronchospasm occurred in patients receiving treatment, especially in those with asthma. ENBREL is a commercially available injectable TNF-blocking treatment for patients with severe rheumatoid arthritis. In addition, interleukin therapy can cause swelling. Depending on how severe these problems are, patients may need to stay in the hospital during treatment. These side effects are usually short-term and they gradually go away after treatment stops. serophene
It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well. This medicine lowers the number of some types of blood cells in your body. Because of this, you or your child may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Failure to take Claravis with food will significantly decrease absorption. Before upward dose adjustments are made, the patients should be questioned about their compliance with food instructions. Champion RH, Burton JL, Burns DA, Breathnach SM, eds. Suspected hepatitis or patients with liver function test elevations that do not normalize: Discontinue use; etiologies should be further investigated. Safety and efficacy have not been established in patients younger than 12 years.
Brănişteanu DE, Cotrutz CE, Luca MC, Molodoi DA, Stoica LE, Ianoşi SL, et al. Morphopathological stigmata in acne fulminans. Rom J Morphol Embryol. 2015. Be sure to ask your doctor if you have any questions about this program. It is very important that you understand and follow all of the requirements. You will not get another prescription unless you follow the instructions for the program. Rhabdomyolysis, sometimes leading to hospitalization or death, has occurred, especially in patients undertaking vigorous physical activity. Isotretinoin may cause bone or muscle problems, including joint pain, muscle pain or stiffness, or difficulty moving. You may get hurt more easily during rough sports. You may heal more slowly. If this medicine is for your child, tell the doctor if you think your child is not growing properly. Ebling Textbook of Dermatology. 6th ed. Oxford, England: Blackwell Science; 1998. 1967-79. The safety and efficacy of once a day dosing has not been established; thus, once a day dosing is not recommended. Isotretinoin may cause some people to have hearing problems within a few weeks after they start taking it. Check with your doctor right away if you or your child have hearing loss, a continuing ringing or buzzing, or any other unexplained noise in the ears. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Palatsi R, Oikarinen A. Hormonal analysis and delayed hypersensitivity reactions in identical twins with severe acne. Acta Derm Venereol. 1979. For effervescent tablets, dissolve the dose in the recommended amount of water, then drink. micronase canada coupons
It is very important that you not share this medicine with anyone else because of the risk of birth defects and other serious side effects. This medicine may affect blood sugar levels. If you or your child are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Failure to take Sotret with food will significantly decrease absorption. Before upward dose adjustments are made, the patients should be questioned about their compliance with food instructions. Female patients must pick up their prescription within 7 days of being filled, and all prescriptions should be limited to a 30-day supply. You can sign up on the internet www. Swallow the capsule whole with a full glass 8 ounces of water or other liquid. It is very important that you or your child not have any cosmetic procedures to smooth your skin eg, dermabrasion, laser while you are taking isotretinoin and for 6 months after stopping it. Isotretinoin can increase your chance of scarring from these procedures. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Female patients of reproductive potential should be instructed regarding pregnancy testing per local protocol and should be told to use at least 2 forms of birth control during and at least 1 month after treatment. Female patients of reproductive potential who have unprotected intercourse any time 1 month before, during, or 1 month after treatment should contact their healthcare provider immediately. Isotretinoin causes birth defects in humans if taken during pregnancy. If you suspect that you may have become pregnant, stop taking this medicine and check with your doctor right away. Avoid overexposing your skin to sunlight, wind, or cold weather. Your skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks of treatment. However, you or your child should not stop taking this medicine unless the skin irritation becomes too severe. Do not use a sunlamp or tanning beds. Biotherapy: Treatment to stimulate or restore the ability of the immune defense system to fight infection and disease. is thus any form of treatment that uses the body's natural abilities that constitute the immune system to fight infection and disease or to protect the body from some of the side effects of treatment.
The US FDA requires a Risk Evaluation and Mitigation Strategy REMS for products containing isotretinoin. It includes a medication guide, elements to assure safe use, and implementation system. For additional information: www. Dose is based on body weight and must be determined by your doctor. This reaction is more often seen in people who also have an allergy to aspirin. Keep away from others not prescribed this drug, including children. Using this medicine while you are pregnant can cause very serious birth defects. Use two forms of effective birth control to keep from getting pregnant one month before beginning treatment, while you are using this medicine even if the medicine is temporarily stopped and for at least 1 month after you stop taking the medicine. The most effective forms of birth control are hormone birth control pills, patches, shots, vaginal rings, or implants, an IUD, or a vasectomy for men. One of these forms of birth control should be combined with a condom, a diaphragm, or a cervical cap. Lages RB, Bona SH, Silva FV, Gomes AK, Campelo V. Acne fulminans successfully treated with prednisone and dapsone. An Bras Dermatol. Jul-Aug 2012. The information contained in the Truven Health Micromedex products as delivered by Drugs. Isotretinoin may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, check with you doctor right away. AND during each month of treatment. Some experts recommend obtaining an additional test 5 weeks after the discontinuation of treatment. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. discount alendronate roche
Wakabayashi M, Fujimoto N, Uenishi T, Danno K, Tanaka T. A case of acne fulminans in a patient with ulcerative colitis successfully treated with prednisolone and diaminodiphenylsulfone: a literature review of acne fulminans, rosacea fulminans and neutrophilic dermatoses occurring in the setting of inflammatory bowel disease. Dermatology. 2011. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Allison MA, Dunn CL, Person DA. Acne fulminans treated with isotretinoin and "pulse" corticosteroids. Pediatr Dermatol. 1997 Jan-Feb. Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit. IL-2 and several types of colony-stimulating factors CSF, GM-CSF, G-CSF. Isotretinoin comes with a patient information form and Medication Guide. It is very important that you read and understand this information. Be sure to carefully follow these instructions and ask your doctor if you have any questions. For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing. Iqbal M, Kolodney MS. Acne fulminans with synovitis-acne-pustulosis-hyperostosis-osteitis SAPHO syndrome treated with infliximab. J Am Acad Dermatol. 2005 May. Consult WARNINGS section for additional precautions. Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016 May.
Biotherapy also called biological therapy or immunotherapy often employs substances called biological response modifiers BRMs. The body normally produces low levels of BRMs in response to infection and disease. Use with caution. May make these conditions worse. If the total nodule count has been reduced by more than 70% prior to completing 15 to 20 weeks of treatment, the drug may be discontinued. After a period of 2 months or more off therapy, and if warranted by persistent or recurring severe nodular acne, a second course of therapy may be initiated. The optimal interval before retreatment has not been defined for patients who have not completed skeletal growth. Long-term use of Claravis, even in low doses, has not been studied, and is not recommended. It is important that Claravis be given at the recommended doses for no longer than the recommended duration. Do not take vitamin A or any vitamin supplement containing vitamin A while taking this medicine, unless otherwise directed by your doctor. To do so may increase the chance of side effects. This drug usually has no side effects. If you have any unusual effects, contact your doctor or pharmacist promptly. Keep out of the reach of children. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Cunliffe WJ, Gollnick H. Acne fulminans. Cunliffe WJ, Gollnick H. Acne. Diagnosis and Management. London, England: Martin Dunitz Ltd; 2001. 84-6. Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol. ziprasidone
Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure. Patients should be advised to avoid sharing this drug with anyone, even those with similar conditions. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Hepatic: Liver function tests at baseline and then at weekly to biweekly intervals until the response is established. Do not crush, break, chew, or suck the capsule. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. This medicine should be used with caution in teenagers, especially those with bone problems or diseases. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. You or your child should not donate blood to a blood bank while using isotretinoin or for 30 days after you stop taking it. This is to prevent a pregnant patient from receiving blood that contains the medicine. Honma M, Murakami M, Iinuma S, et al. Acne fulminans following measles infection. J Dermatol. 2009 Aug. Friedlander SF. Effective treatment of acne fulminans-associated granulation tissue with the pulsed dye laser. Pediatr Dermatol. 1998 Sep-Oct. Wollina U, Gesina H, Koch A, Kostler E. Case reports: acne fulminans in Marfan syndrome. J Drugs Dermatol. 2005 Jul-Aug. Different brands may not work the same way. If you refill your medicine and it looks different, check with your pharmacist.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. The safety of once daily dosing with Accutane has not been established. Once daily dosing is not recommended. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. This medicine may increase pressure in your head. This may increase your risk of vision loss or serious brain problems. Check with your doctor right away if you have a bad headache, blurred vision, dizziness, nausea or vomiting, or seizures. This drug is only available through a restricted program under a REMS called iPLEDGETM. Under the REMS, prescribers, patients, pharmacies, and distributors must enroll and be registered in the program. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, redness, soreness, or itching skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. buy detrol online canada
Capsules should be swallowed with a full glass of liquid. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Kalbarczyk K, Ciupinska M. Complications during treatment with Roaccutane, acne fulminans 2001. Dermatol Klin Wroclaw. 2001. Any patient requesting refills requires a new prescription and a new authorization from the iPLEDGE program. Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. The safety of once daily dosing with Sotret has not been established. Once daily dosing is not recommended. Tell your doctor right away if you or your child have abdominal or stomach pain, rectal bleeding, or severe diarrhea. These may be symptoms of a serious condition called inflammatory bowel disease. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. GP arranged an appointment with my local dermatologist and they started me on Isotrettin Accutane in the first few weeks I noticed my skin started to clear up abit and I was so glad I had started on it I had the side effects of chapped lips dry skin etc and I am now on my 5th week and my skin has become worse than ever! Patients should take some formulations of this drug with food. American Academy of Dermatology. Ten Things Physicians and Patients Should Question. Choosing Wisely. Store at 20 to 25C; protect from light. Gordon PM, Farr PM, Milligan A. Acne fulminans and bone lesions may present to other specialties. Pediatr Dermatol. 1997 Nov-Dec.
BIRTH DEFECTS Pregnancy Category X: This drug should not be used by female patients who are or may become pregnant. There is an extremely high risk that severe birth defects will result if pregnancy occurs while taking this drug in any amount, even for short periods of time; potentially any fetus exposed during pregnancy can be affected. There are no accurate means of determining whether an exposed fetus has been affected. Heydenreich G. Testosterone and anabolic steroids and acne fulminans. Arch Dermatol. 1989 Apr. Do not keep outdated medicine or medicine no longer needed. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of isotretinoin in the elderly. However, elderly patients may have a greater risk of problems and side effects when taking isotretinoin. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. Metabolic: Fasting lipid and blood glucose levels at baseline and then at weekly to biweekly intervals until the response is established. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. store carafate uk
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The side effects of biological therapy depend on the type of treatment. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist. buy now tamoxifen pharmacy uk tamoxifen
Patients should be told to avoid donating blood during and up to 1 month after discontinuation of treatment. If you are a woman who is able to have children, you must have 2 pregnancy tests before beginning treatment with isotretinoin to make sure you are not pregnant. The second pregnancy test must be taken at least 19 days after the first test and during the first 5 days of the menstrual period immediately prior to beginning treatment. In addition, you must have a pregnancy test each month while you are taking this medicine and 1 month after treatment is completed. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider.
Inform patients that this drug may decrease night vision, and they should use caution when driving or operating machinery. Isotretinoin may cause dryness of the eyes. If you or your child wear contact lenses, your eyes may be more sensitive to them during the time you are taking isotretinoin and for up to 2 weeks after you stop taking it. To help relieve dryness of the eyes, check with your doctor about using a lubricating solution, such as artificial tears. If eye inflammation occurs, check with your doctor right away. Isotretinoin must not be used to treat women who are able to bear children unless other forms of treatment have been tried first and have failed. Isotretinoin must not be taken during pregnancy because it causes birth defects in humans. If you are able to bear children, it is very important that you read, understand, and follow the pregnancy warnings for isotretinoin. tekz.info amitriptyline
Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away. Serious skin reactions can occur with this medicine. Check with your doctor right away if you or your child have any of the following symptoms while using this medicine: blistering, peeling, or loosening of the skin, chills, diarrhea, itching, joint or muscle pain, rash, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness. Isotretinoin must not be taken by women of reproductive age unless two effective forms of birth control have been used for at least 1 month before the start of treatment. Contraception must be continued during the period of treatment, which is up to 20 weeks, and for 1 month after isotretinoin is stopped. Be sure you have discussed this information with your doctor.